Interaction of cationic phosphorus dendrimers with lipid membranes

Ionov, M.; Wróbel, D.; Gardikis, K.; Hatziantoniou, S.; Demetzos, C.; Majoral, J. P.; Klajnert, B.; Bryszewska, M.

doi:10.7508/ijnd.2011.01.007

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	Interaction of cationic phosphorus dendrimers with lipid membranes
Article 8, Volume 2, Issue 1, Summer 2011, Page 55-60 PDF (447 K)
Document Type: Reasearch Paper
DOI: 10.7508/ijnd.2011.01.007
Authors
M. Ionov ¹; D. Wróbel¹; K. Gardikis²; S. Hatziantoniou²; C. Demetzos³; J. P. Majoral⁴; B. Klajnert¹; M. Bryszewska¹
¹Department of General Biophysics, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland.
²Department of Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou 15771, Athens, Greece.
³Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou 15771, Athens, Greece.
⁴Laboratorie de Chimie de Coordination, CNRS, UPR 8241 205, route de Narbonne 31077, Toulouse, France.
Abstract
Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G3 and G4. DSC and ζ -potential measurements have shown that liposomal-dendrimeric molecular recognition occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids that interact with CPDs is dependent on the dendrimers generation. These results can be used in order to rationally design mixed modulatory liposomal locked-in dendrimeric, drug delivery nano systems.
Keywords
Dendrimer; Lipid membrane; Dendrimer/membrane interaction


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