Imatinib loaded pegylated Poly Propylene Imine dendrimer for delivery to leukemic cells; fabrication of formulation and evaluation

Karthikeyan, Ramadoss; Vijayraj Kumar, Palanirajan; Sai Koushik, Oruganti

doi:10.7508/ijnd.2016.04.009

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Imatinib loaded pegylated Poly Propylene Imine dendrimer for delivery to leukemic cells; fabrication of formulation and evaluation

Article 9, Volume 7, Issue 4, Autumn 2016, Page 336-348 PDF (918 K)

Document Type: Reasearch Paper

DOI: 10.7508/ijnd.2016.04.009

Authors

Ramadoss Karthikeyan

¹; Palanirajan Vijayraj Kumar²; Oruganti Sai Koushik³

¹Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, India

²Faulty of Pharmaceutical Sciences, UCSI University, Kualalampur, Malaysia

³Vignan Pharmacy College, Vadlamudi, India

Abstract

PEGylated polypropyleneimine (PPI) dendritic scaffold was used for the delivery of an anti-leukemic drug, Imatinib. The current study evolves and emerges the use PEGylated PPI dendritic scaffold for the delivery of this drug. In this Imatinib was synthesized and loaded with PEGylated PPI dendritic scaffold. Parameters such as FT-IR, NMR, SEM, drug release, DSC and hemolytictoxicity are required. Other parameters such as drug entrapment of both PEGylated and non-PEGylated systems were comparatively determined. Drug-loading capacity was found to be increased with the PEGylation and reduces the haemolytic toxicity as well as drug release rate. By this, prolonged delivery of Imatinib was found to be suitable with this system. By delivering the drug for a prolonged period of time at a controlled rate, we expect that this approach will improve the management of drug therapy in leukemic patients.

Keywords

Antileukemic activity; Dendritic scaffold; Imatinib; PEGylated dendrimers; Prolonged release

Main Subjects

Nano Bio Technology; Nanomaterial; Nanomedicine; Nanotechnology

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